ASEMV2018 Program

7:00pm – 9:00pm

Chair: Michael Graner, University of Colorado, Denver, USA

7:00 – 7:10pm Welcome
Michael Graner, University of Colorado, Denver, USA

7:10 – 7:20pm ASEMV: events, working groups, review rosters, etc.
Stephen Gould Johns Hopkins University, Baltimore, USA

7:20 – 7:40pm Expanding the repertoire of peripheral coding and non-coding RNA biomarkers for brain tumors
Anna Krichevsky BWH/Harvard, Boston, USA (abstract #1)

7:40 – 8:00pm Comparison of exRNA and EV isolation techniques reveals exRNA carrier
subtypes
Louise Laurent UC San Diego, La Jolla, USA (#2)

8:00 – 8:20pm The impact of assays and analysis on exRNA diversity
Kendall van Keuren Jensen TGen, Phoenix, USA (#3)

8:20 – 8:40pm Vesicle-cloaked virus clusters are the optimal units for inter-organismal viral
transmission
Marianita Santiana NHLBI/NIH, Washington DC, USA (#4)

8:40 – 9:00pm Latest findings on exosomes from viral infections with specific zip codes
Fatah Kashanchi George Mason University, Manassas, USA (#5)

9:00 – 11:00pm Reception

8:30am – 12:00pm

Chair: Stephen Gould, Johns Hopkins University, Baltimore, USA

8:30 – 8:45am Extracellular vesicles in the evolution of glioma initiating cells
Janusz Rak McGill University, Montreal, Canada (abstract #6)

8:45 – 9:00am Bacterial outer membrane vesicles: from membrane blebs to medical solutions
Lisa Morici Tulane University, New Orleans, USA (#7)

9:00 – 9:15am Tick exosomal microRNAs manipulate vertebrate host gene expression
Michail Kotsyfakis CAS, Budweis, Czech Republic (#8)

9:15 – 9:30am Interferometry for vesicle analysis
Selim Unlu Boston University, Boston, USA (#9)

9:30 – 9:45am Development of a broad use interferometry platform for exosome analysis
George Daaboul NanoView, Boston, USA (#10)

9:45 – 10:00am HIV and opioid mediated impairment of microglial functioning involves astrocyte
derived EVs
Shilpa Buch University of Nebraska, Lincoln, USA (#11)

10:00 – 10:30am Break

10:30 – 10:45am High-throughput electrochemical sensor for clinical EV analyses
Hakho Lee MGH/Harvard, Boston, USA (#12)

10:45 – 11:00am Cytokines in EVs: A hidden system of intercellular communication
Leonid Margolis NICHD/NIH, Washington, DC, USA (#13)

11:00 – 11:15am Aggregatibacter actinomycetemcomitans outer membrane vesicle heterogeneity is
growth phase-dependent
Justin Nice Lehigh University, Bethlehem (PA), USA (#14)

11:15 – 11:30am Exosomes and extracellular RNAs: from biomarkers to signaling in heart disease
Saumya Das MGH/Harvard, Boston, USA (#15)

11:30am – 11:45pm Quantification of cancer EV populations using super-resolution microscopy
Tijana Talisman City of Hope, Duarte, USA (#16)

11:45am – 12:00pm Comparative and integrative proteomics of blood and semen identifies tissue-specific extracellular markers enriched in healthy and disease states
Chioma Okeoma Stony Brook University, Stony Brook, USA (#17)

12:00pm – 1:30pm Lunch

9:30pm – 11:30pm

Abstract #4:   Vesicle-Cloaked Virus Clusters are the Optimal Units for Inter-Organismal Viral Transmission
M. Santiana, S. Ghosh, B. Ho, V. Rajasekaran, WL. Du, Y. Mutsafi, D. De Jesus-Diaz, S. Sosnovtsev, E. Levenson, G. Parra, P. Takvorian, A. Cali, C. Bleck, A. Vlasova, L. Saif, J. Patton, P. Lopalco, A. Corcelli, K. Green, N. Altan-Bonnet

#6:   Extracellular Vesicles in the Evolution of Glioma Initiating Cells
Janusz Rak, Cristiana Spinelli, Delphine Granier, Laura Montermini, Brian Meehan, Dongsic Choi

#14:   Aggregatibacter actinomycetemcomitans outer membrane vesicle heterogeneity is growth phase-dependent
Justin Nice, Angela C. Brown

#16:   Quantification of pancreatic cancer-enriched extracellular vesicle populations using super resolution microscopy
Kathleen M. Lennon, Devin L. Wakefield, Adam L. Maddox, Marcia M. Miller, Ajay Goel, Kendall Van Keuren-Jensen, Tijana Jovanovic-Talisman

#18:   Nanoscopy approach to image and quantify diverse extracellular vesicles
Shivani Sharma

#20:   Exosomes: regenerative medicine without the cells
Linda Marban

#22:   Mechanism and application of ARMMs
Quan Lu

#23:   Proteolytic neutrophil exosomes transfer COPD from humans to mice
Russell DW, Genschmer KR, Szul T, Xu X, Viera L, Abdalla, McNicholas CM, Wells JM, Gaggar A, Blalock JE

#26:   ExRNA Atlas resource reveals distinct extracellular RNA cargo types present across human body fluids
Oscar D. Murillo, William Thistlethwaite, Joel Rozowsky, Sai Lakshmi Subramanian, Rocco Lucero, Neethu Shah, Andrew R. Jackson, Srimeenakshi Srinivasan, Allen Chung

#36:   ALIX regulates tumour-mediated immunosuppression by controlling EGFR activity and PD-L1 presentation
James Monypenny, Hanna Milewicz, Fabian Flores-Borja, Gregory Weitsman, et al., Jeremy G. Carlton, Tony Ng

#40:   Dual Promise of Extracellular MicroRNAs in the Diagnosis and Pathology of Alzheimer’s Disease
Ursula S. Sandau, Jack T. Wiedrick, Theresa A. Lusardi, Christina A. Harrington, Trevor J. McFarland, Babett Lind, Jodi A. Lapidus, Douglas R. Galasko, Joseph F. Quinn, John P. Nolan, Julie A. Saugstad

#48:   RANK-containing regulatory EVs released by osteoclasts
L. Shannon Holliday, Jian Zuo, Victor Spicer, Oleg Krokhin, Wellington J. Rody Jr.

#50:   Physical coherence and network analysis to decode the biogenesis of exosomes
Suresh Mathivanan

#52:   The last dance of a dying cell
Georgia Atkin-Smith, Rochelle Tixeira, Lanzhou Jiang, Sarah Caruso, Stephanie Paone, Bo Shi, Amy Hodge, Jascinta Santavanond, Stephanie Rutter, Michael Parkes, Dilara Ozkocak, Thanh Phan, Amy Baxter, Ivan Poon

#58:   Investigating the role of fibulin-3 and exosomes in macular degeneration
Jasmine Geathers, Weiwei Wang, Alistair J. Barber, Jeffrey M. Sundstrom

#62:   Metabolic control of outer membrane vesicle production in Francisella spp.
Vinaya Sampath, Maheen Rashid, David Thanassi

#64:   Evaluation of a Microvesicle-Based Poly-Ligand Opt-Out Assay for Screening Plasma Samples from Men at Risk for Prostate Cancer
Heather A. O’Neill, Xixi Wei, Xiaowei Liu, Radhika Santhanam, Daniel Magee, Anthony Helmstetter, Tassilo Hornung, Mark R. Miglarese, Günter Mayer, Michael Famulok, David Spetzler

#68:   Exosomes from Pancreatic Cancer Stem Cells Mediate Intra Tumor Communication and Facilitate Hippo Pathway Regulation
Ruivo, CF, Martins J, Bastos, N, Adem B, Silva S, Melo CA, Higuera SC, Valverde MC, Fernandez FA, Bayón FG, Fraga M, Osório H, Machado J, Kalluri R, Melo SA

#70:   Liquid biopsy: circulating tumor exosomes’ lineage traced back to their cell and tissue of origin
Navneet Dogra, Mehmat Eren Ahsen, Stacey M. Gifford, Benjamin H. Wunsch, Joshua T. Smith, Sungcheol Kim, Rachel Weil, Kamlesh Yadav, Ronald Gordon, Carlos Cordon Cardo, Ashutosh K Tewari, Gustavo Stolovitzky

#72:   Detection of an EV-based metastasis signature in clinical biofluids
John Lewis

#76:   Isolation of molecularly homogeneous subpopulations of exosomes
Mikhail Skliar

#80:   Hitchhiking extracellular vesicles to jump: Extracellular vesicles serve as delivery vehicles for LINE-1 retrotransposons
Yumi Kawamura, Anna Sanchez Calle, Yusuke Yamamoto, Taka-Aki Sato, Takahiro Ochiya

#82:   Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer
Pedro Correa de Sampaio, Sujuan Yang, Sara P. Y. Che, Paul Kurywchak, Jena L. Tavormina, Liv B. Gansmo, Michael Tachezy, Maximilian Bockhorn, Florian Gebauer, Amanda R. Haltom, Sonia A. Melo, Valerie S. LeBleu, Raghu Kalluri

#88:   Extracellular vesicles in oncogenic signaling and autophagy
Stephanie N. Hurwitz, Mujeeb Cheerathodi, Dingani Nkosi, David G. Meckes Jr.

#94:   Profiling the vesicular and non-vesicular miRNA secretome
Imre Mager

#100:   Understanding Exosome Biogenesis in Hypothalamic Cells through Studying of Protein Dynamic using Pulsed-SILAC
Chee Fan Tan, Jung Eun Park, Wilford Tse, Ser Sue Ng, Bamaprasad Dutta, Melvin Leow, Walter Wahli, Siu Kwan Sze

#102:   Increased secretion of miR-193a-3p by cardiomyocytes under stress inhibits proliferation and activation of cardiac fibroblasts
Rodosthenis S. Rodosthenous, Mun Chun Chan, Kirsty Danielson, Ravi Shah, Bridget Simonson, Olivia Ziegler, Ashish S. Yeri, Saumya Das

#104:   Exosome-like nanoparticles from ginger rhizomes inhibited NLRP3 inflammasome activation
Jiujiu Yu, Xingyi Chen, Baolong Liu

#104:   Inflaming the Masses: Glioma EVs Promote Inflammatory, Degradative, and Metabolic Responses in Normal Brain Cells
Michael W Graner, Mary Wang, Andrew Bubak, Anthony Fringuello, Steve Ojemann, Aviva Abosch, Petr Paucek, Maria Nagel

#106:   Intranasal delivery of lncRNA-Cox2 siRNA loaded exosomes ameliorates opioid-mediated microglial dysfunction in mice
Guoku Hu, Ke Liao, Fang Niu, Shilpa Buch

#108:   The role of BST-2-expressing extracellular vesicles in cancer cell proliferation
Folnetti Alvarez, Nadia Shouman, Chioma M Okeoma

#110:   Micro – size exclusion chromatography combined with direct PCR for rapid and sensitive detection of extracellular vesicle – associated nucleic acids
Li Sun, David G. Meckes Jr.

#112:   Multiplexed profiling of single extracellular vesicles
Kyungheon Lee, Kyle Fraser, Bassel Ghaddar, Katy Yang, Eunha Kim, Leonora Balaj, E. Antonio Chiocca, Xandra O. Breakefield, Hakho Lee, Ralph Weissleder

#114:   Exosomes secreted by tumor cells promote the generation of suppressive monocytes
Jennifer A Lenz, Nhungoc Luong, Jaime F Modiano, Julie K Olson

#116:   Exosomes in semen inhibit HIV-1 independent of exosome-mediated immune regulation
Jennifer L. Welch, Thomas M. Kaufman, Hussein Kaddour, Jack T. Stapleton, Chioma M Okeoma

#118:   HIV-1-suppressed patients plasma and semen exosomes contain protective levels of anti-retroviral (ART) drugs
Jennifer L. Welch, Jack T. Stapleton, Hussein Kaddour, Lee Winchester, Courtney V. Fletcher, Chioma M Okeoma

#120:   Highly Sensitive qPCR-based Assay for the Detection of EGFR Activating and Resistance Mutations in Plasma from Non-Small Cell Lung Cancer Patients
X. Zhang, E. Castellanos-Rizaldos, V.R. Tadigotla, D.G. Grimm, C. Karlovich, L. E. Raez, J.K. Skog

#124:   Exosome isolation using a microfluidics chip reveals specific signaling pathways associated with their protein profiles in ovarian cancer
Kalpana Deepa Priya Dorayappan, Roman Zingarelli, Colin L. Hisey, Miranda Gardner, Michelle D.S. Lightfoot, Meghan M. Flannery, Brentley Q. Smith, John Hays, Michael Freitas, Derek J Hansford, Zhang Jianying, David E. Cohn, Karuppaiyah Selvendiran

#126:   The Importance of Frozen Urine Pre-Treatment Prior to Exosomal RNA Purification on RNA Recovery for Exosomal miRNA Profiling
David A. Armstrong, John A. Dessaint, Carol S. Ringelberg, Haley F. Hazlett, Louisa Howard, Moemen A.K. Abdalla, Roxanna L. Barnaby, Bruce A. Stanton, Mark A. Cervinski, Alix Ashare

#128:   Intrauterine weekly expression of long noncoding RNA and mRNA for synaptic vesicle molecules among spontaneous preterm birth and preeclampsia
Nanbert Zhong

#130:   Immunomodulatory exosomes derived from human mesenchymal stem cells for treatment of acute lung injury
Alvin Tieu, Duncan J Stewart, Casey Lansdell, Manoj M Lalu

#132:   The natural killer cell isolation and harvesting of natural killer cell-derived exosomes for their therapeutic use
Yoon-Tae Kang, Zeqi Niu, Thomas Hadlock, Sunitha Nagrath

#134:   Microfluidic isolation of the cancer cell-derived exosomes using extracellular vesicular lipid-protein binding affinity
Yoon-Tae Kang, Colin Palacios-Rolston, Emma Purcell, Ting-Wen Lo, Nithya Ramnath, Sunitha Nagrath

#136:   Functional Role of Exosomes in HTLV-1 Infection
Pinto DO, Anderson MA, DeMarino C, Pleet ML, Enose-Akahata Y, Akpamagbo Y, Lepene B, Jones J, Jacobson S, Kashanchi F

#138:   Role of exosomes in the development of dendritic filopodia and spines
Mikin Patel, Mingjian Shi, Caitlin McAtee, Daisuke Hoshino, Andrew McKenzie, Donna Webb, Alissa Weaver

#140:   Ionizing radiation and autophagy activation modulates EV secretion and induces killing of HIV-1 infected myeloid and T-cells
Pinto DO, DeMarino C, Vo TT, Iordanskiy S, Heredia A, Batrakova E, Kashanchi F

#142:   Immunophenotyping extracellular vesicles using Amnis imaging technology
Sherree L. Friend, Haley R. Pugsley, Bryan R. Davidson, Phil Morrissey

#146:   Novel modes of EV release by GDE2 and GDE3
Reuben Levy-Myers, Mateusz Dobrowolski, Shanthini Sockanathan

#148:   Isolation and characterization of plasma extracellular vesicles enriched for neuronal origin
Maja Mustapic, Edward J. Goetzl, Dimitrios Kapogiannis

#150:   Exosomal Activation of HIV-1 Latency Involves Exosomal c-Src
Robert Barclay, Yao A. Akpamagbo, Catherine DeMarino, Michelle L. Pleet, Gifty Mensah, Myosotys Rodriguez, Gavin Sampey, Sergey Iordanskiy, Nazira El-Hage, Fatah Kashanchi

#152:   Ebola VP40 regulates extracellular vesicle biogenesis to cause immune cell dysfunction
M.L. Pleet, J. Erickson, C. DeMarino, A. Mathiesen, M. Cowen, R. Barclay, S. Iordanskiy, G. Sampey, L.I. Prugar, S W. Stonier, J.M. Dye, W. Zhou, L.A. Liotta, B. Lepene, M.J. Aman, F. Kashanchi

#154:   Extracellular Vesicles Reveal Abnormalities In Neuronal Iron Metabolism In Restless Legs Syndrome
Sahil Chawla, Seema Gulyani, Richard P Allen, Christopher J Earley, Xu Li, Peter Van Zijl, Dimitrios Kapogiannis

#156:   Exosome production is linked to impaired autophagy flux via miR-155 in alcoholic liver disease
Istvan Furi, Shashi Bala, Mrigya Babuta, Patrick Lowe, Karen Kodys, Donna Catalano, Gyongyi Szabo

#158:   Extracellular Vesicle Manipulation of the Leukemic Microenvironment
Theo Borgovan, Chibuikem Nwizu, Laura Goldberg, Mark Dooner , Sicheng WenWen, Michael Del Tatto, Peter Quesenberry

#164:   Analysis of Exosomes for Proteomics by Mass Spectrometry
David M. Lubman, Mingrui An, Kyle Cuneo, Jing Wu, Jie Zhang, Jianhui Zhu

#166:   Astrocyte-derived extracellular vesicles shed in response to IL-1beta up-regulate amyloidogenic processing in neurons
Zhigang Li, Raha M. Dastgheyb, Seung-Wan Yoo, Amrita Datta Chaudhuri, Carlos Nogueras-Ortiz, Dimitrios Kapogiannis, Norman J. Haughey

#168:   Development of MSC-NTF (NurOwn®) derived extracellular vesicles for the treatment of neurodegenerative diseases
Haggai Kaspi, Jonathan Semo, Nathalie Abramov, Ralph Kern, Revital Aricha

#170:   Multiplexed profiling of single extracellular vesicles
Ala Jo, Kyungheon Lee, Kyle Fraser, Bassel Ghaddar, Katy Yang, Eunha Kim, Leonora Balaj, E. Antonio Chiocca, Xandra O. Breakefield, Hakho Lee, Ralph Weissleder

#172:   Exosome-like nanoparticles from ginger rhizomes inhibited NLRP3 inflammasome activation
Jiujiu Yu, Xingyi Chen, Baolong Liu

#173:   Vesicular Transmission of Rotavirus Deceives the Host Mucosal Immune Response
Sourish Ghosh, Marianita Santiana, Nihal Altan-Bonnet

#174:   Progress in Separation of Extracellular Vesicles from Brain Tissue of Human, Macaque, and Mouse
Yiyao Huang, Laura Vella, Vasiliki Machairaki, Linzhao Cheng, Andrew F. Hill, Lei Zheng, Kenneth W. Witwer

1:30pm – 5:00pm

Chair: Tushar Patel, Mayo Clinic, Jacksonville, USA

1:30 – 1:45pm Nanoscopy approach to image and quantify diverse extracellular vesicles
Shivani Sharma UCLA, Los Angeles, USA (abstract #18)

1:45 – 2:00pm Zika virus exploits extracellular vesicle pathways
David Meckes Florida State University, Tallahassee, USA (#19)

2:00 – 2:15pm Exosomes: regenerative medicine without the cells
Linda Marban Capricor, Los Angeles, USA (#20)

2:15 – 2:30pm Listeria monocytogenes virulence factors are secreted in biologically active
extracellular vesicles
Carolina Coelho Johns Hopkins University, Baltimore, USA (#21)

2:30 – 2:45pm Mechanism and application of ARMMs
Quan Lu Harvard School of Public Health, Boston, USA (#22)

2:45 – 3:00pm Proteolytic neutrophil exosomes transfer COPD from humans to mice
Derek Russell University of Alabama, Birmingham, USA (#23)

3:00 – 3:30pm Break

3:30 – 3:45pm Extracellular vesicles in the immunopathology of infectious diseases
Georges Grau University of Sydney, Sydney, Australia (#24)

3:45 – 4:00pm Development of software tools for the development of a multiplex-to-single
extracellular vesicle characterisation pipeline.

Joshua Welsh NCI/NIH, Washington DC, USA (#25)

4:00 – 4:15pm ExRNA Atlas resource reveals distinct extracellular RNA cargo types present
across human body fluids
Matt Roth Baylor College of Medicine, Houston, USA (#26)

4:15 – 4:30pm Light scattering tools for rapid screening and deep characterization of
therapeutic nanoparticles
John Champagne Wyatt Technologies, Santa Barbara, USA (#27)

4:30 – 4:45pm Exosome biogenesis at plasma and endosome membranes
Francis Fordjour Johns Hopkins University, Baltimore, USA (#28)

4:45 – 5:00pm Designed exosomes for cancer immunotherapy
In-San Kim KIST, Seoul, South Korea (#29)

5:00 – 7:30pm Dinner

7:30pm – 9:30pm

Chair: Tijana Talisman, City of Hope, Duarte, USA

7:30 – 7:50pm ARC; before exosomes
Paul Worley Johns Hopkins University, Baltimore, USA ( abstract #30)

7:50 – 8:10pm RNA transfer across synaptic boutons using extracellular vesicles and a viral-like
mechanism
Travis Thomson University of Massachusetts, Worcester, USA (#31)

8:10 – 8:30pm Virus-like mechanisms of neuronal extracellular vesicle biogenesis
Jason Shepherd University of Utah, Salt Lake City, USA (#32)

8:30 – 8:50pm Drugs of abuse alter the release of extracellular vesicles in the brain
Christie Fowler UC Irvine, Irvine, USA (#33)

8:50 – 9:10pms Exosomal proteins: mechanistic insights and biomarker potential
Ayuko Hoshino Weill Cornell Medicine, New York, USA (#34)

9:10 – 9:30pm Arthropod exosomes as slingshots for arboviral transmission
Hameeda Sultana Old Dominion University, Norfolk, USA (#35)

8:30am – 12:00pm

Chair: Michael Olin, University of Minnesota, St. Paul, USA

8:30 – 8:45am ALIX regulates tumour-mediated immunosuppression by controlling EGFR activity
and PD-L1 presentation
James Monypenny King’s College London, London, UK (abstract #36)

8:45 – 9:00am Melanoma-derived exosomes in checkpoint-mediated immune suppression
Wei Guo University of Pennsylvania, Philadelphia, USA (#37)

9:00 – 9:15am Control of oligodendrocyte precursor proliferation: a role for regulated release of
CNTFRa
Shanthini Sockanathan Johns Hopkins University, Baltimore, USA\ (#38)

9:15 – 9:30am Milk exosomes accumulate in the intestinal mucosa and peripheral tissues in wild-
type pups nursed by exosome and cargo tracking dams
Janos Zempleni University of Nebraska, Lincoln, USA (#39)

9:30 – 9:45am Dual promise of extracellular microRNAs in the diagnosis and pathology of
`Alzheimer’s disease
Julie Saugstad Oregon Health and Science University, Portland, USA (#40)

9:45 – 10:00am Exosome trafficking in yeast and zebrafish
Hui-Ling Chiang Penn State University, Hershey (PA) USA (#41)

10:00 – 10:30am Break

10:30 – 10:45am Extracellular vesicles from virus-infected cells lead to long-term endothelial cell
reprogramming
Dirk Dittmer University of North Carolina, Chapel Hill, USA (#42)

10:45 – 11:00am Stimulus dependent cargo inclusion regulates the neuronal response to astrocyte
derived extracellular vesicles
Norm Haughey Johns Hopkins University, Baltimore, USA (#43)

11:00 – 11:15am Macrophage-exosomes in atherosclerosis cardiovascular disease
Robert Raffai VA/UCSF, San Francisco, USA (#44)

11:15 – 11:30am Extracellular vesicles as epigenetic mediators of systemic communication in
murine experimental sepsis
Candice Brown West Virginia University, Morgantown, USA (#45)

11:30 – 11:45am Clinical scale production and wound healing activity of human adipose derived
mesenchymal stem cell extracellular vesicles from a hollow fiber bioreactor
John Cadwell FiberCell Systems, Frederick, USA (#46)

11:45am – 12:00pm A platform for cell-engineered exosome therapies
Chulhee Choi KAIST, Daejon, South Korea (#47)

12:00pm – 7:30pm Lunch – Open – Dinner

7:30pm – 9:30pm

Chair: Leonora Balaj, MGH/Harvard, Boston, USA

7:30 – 7:50pm RANK-containing regulatory EVs released by osteoclasts
L. Shannon Holliday University of Florida, Gainesville, USA (abstract #48)

7:50 – 8:10pm Osteoblastic RANKL acts as an osteogenic signal acceptor recognizing vesicular
RANK secreted from osteoclasts
Masashi Honma University of Tokyo, Tokyo, Japan (#49)

8:10 – 8:30pm Physical coherence and network analysis to decode the biogenesis of exosomes
Suresh Mathivanan La Trobe University, Melbourne, Australia (#50)

8:30 – 8:50pm Molecular and functional heterogeneity of extracellular vesicles
Dolores Di Vizio Cedars Sinai, Los Angeles, USA (#51)

8:50 – 9:10pm The last dance of a dying cell
Ivan Poon La Trobe University, Melbourne, Australia (#52)

9:10 – 9:30pm Engineering of EVs
Samir El-Andaloussi Karolinska Institute, Stockholm, Sweden (#53)

9:30pm – 11:30pm

#7:   Bacterial outer membrane vesicles possess potent antimicrobial activity and disrupt competitor bacterial biofilms
Yihui Wang, Joseph P. Hoffmann, Sarah M. Baker, Kerstin Höner zu Bentrup, Jacob P. Bitoun, Lisa A. Morici

#17:   Comparative and integrative proteomics of blood and semen identifies organ-specific extracellular markers enriched in healthy and disease states
Hussein Kaddour, Jennifer L. Welch, Shruti Sakhare, Victor Paromov, Siddharth Pratap, Chandravanu Dash, Jack T. Stapleton, Chioma M. Okeoma

#21:   Listeria monocytogenes virulence factors are secreted in biologically active Extracellular Vesicles
C Coelho, L Brown*, M Maryam, R Vij, MC. Burnet, JE. Kyle, HM Heyman, J Ramirez, R Prados-Rosales, G Lauvau, ES Nakayasu, NR Brady, A Hamacher-Brady, I Coppens, A Casadevall

#25:   Development of software tools for the development of a multiplex-to-single extracellular vesicle characterisation pipeline
Welsh J.A., Kepley J., McKinnon K., Berzofsky J., Jones J.C.

#28:   Exosome biogenesis at plasma and endosome membranes
Francis Fordjour.

#29:   Designed exosomes for cancer immunotherapy
In-San Kim, M.D., Ph.D.

#33:   Drugs of Abuse Alter the Release of Extracellular Vesicles in the Brain
Valeria Lallai, Christie D. Fowler

#35:   Arthropod exosomes as slingshots for arboviral transmission
Hameeda Sultana

#39:   Milk exosomes accumulate in the intestinal mucosa and peripheral tissues in wild-type pups nursed by exosome and cargo tracking dams
Janos Zempleni, Bijaya Upadhyaya, Mengna Xia, Hideaki Moriyama, Masato Ohtsuka

#41:   Exosome Trafficking in Yeast and Zebrafish
Chelsea Winters, Jingjing Liu, Ly Hong-Brown, Hui-Ling Chiang

#43:   Stimulus dependent cargo inclusion regulates the neuronal response to astrocyte derived extracellular vesicles
Asit Kumar, Amanda Trout, Raha Dastgheyb, Seung-Wan Yoo, Amrita Datta Chaudhuri, Conover Talbot Jr., Haiping Hao, Kenneth W. Witwer, Sheng Wang, Saja Khuder, Robert Cole Norman J. Haughey

#45:   Extracellular vesicles as epigenetic mediators of systemic communication in murine experimental sepsis
Candice M. Brown, Divine C. Nwafor, Allison L. Brichacek, Catheryne A. Gambill, Ahmad Dakhlallah, Timothy D. Eubank, Clay B. Marsh, Duaa Dakhlallah

#49:   Osteoblastic RANKL acts as an osteogenic signal acceptor recognizing vesicular RANK secreted from osteoclasts
Masashi Honma, Yuki Ikebuchi, Shigeki Aoki, Madoka Hayashi, Yoshiaki Kariya, Hiroshi Suzuki

#55:   Extracellular Vesicle Biomarkers Predict Alzheimer’s Disease in the Baltimore Longitudinal Study of Aging
Dimitrios Kapogiannis.; Maja Mustapic; Michelle Shardell; Sean Berkowitz; Thomas Diehl; Ryan Spangler; Joyce Tran; Michael Lazaropoulos; Sahil Chawla; Seema Gulyani; Erez Eitan; Yang An; Chiung-Wei Huang; Susan Resnick; Edward Goetzl; Luigi Ferrucci

#57:   Characterization of the molecular interaction between exosomal ceramide and beta amyloid, revealing a role of ceramide in Abeta aggregation and toxicity.
Elsherbini A., Kirov A., Dinkins M., Leanhart S., Zhong L., Wang G., Jiang X., Zhu Z., Spassieva S., Qin H. Burgert A., Schubert-Unkmeir A. , Sauer M., Bieberich E.

#59:   Immortalised human neural stem cell platform for the production of exosome-based therapeutics
Randolph Corteling

#63:   Characterization of microvesicles for cancer diagnostics
Vanessa Correll, Paul Boutros, Anca Dobrian, Thomas Kislinger, Julius Nyalwidhe, Lifang Yang, O. John Semmes

#65:   Role of exosomal miRNAs as a biomarker for mitochondrial dysfunction
Ju Young Ahn, Sayantan Datta, Elga Bandeira, Marisol Cano, James Handa, Michael Paulaitis

#67:   Preanalytical steps enabling optimal exosome based liquid biopsy in cancer
Antonio Chiesi, Claudio Corallo, Marta Venturella, Laura Bianciardi, Silvia Mancianti, Davide Zocco

#69:   Changes in macrophage polarization, in response to formalin-fixed and/or electroporated lung cancer exosomes, depend on the pre-existing macrophage polarization state
Jeremy B. Jones, Gina T. Bardi, Joshua L. Hood M.D. Ph.D.

#75:   An efficient and high-purity method for EV isolation from urine samples
Gayatri Premasekharan, Archana Gupta, Frank Hsiung

#77:   Exosomes promote cancer progression by regulating the anti-tumor immune response
Mauro Poggio, TJ Hu, Chien-Chun Pai, Brandon Chu, Cassandra Belair, Anthony Chang, Elizabeth Montabana, Qi Fu, Lawrence Fong, Robert Blelloch

#79:   Leveraging machine-learning assisted histopathology to assess large oncosome biogenesis in tissue
Andries Zijlstra

#81:   Tools for live-monitoring of exosome release from single cells
Maarten P. Bebelman, Frederik J. Verweij, Philippe Bun, Martine J. Smit, Guillaume van Niel, Dirk Michiel Pegtel

#85:   Diabetes mellitus alters extracellular vesicle concentration, cargo and function
Nicole Noren Hooten, David W. Freeman, Erez Eitan, Jamal Green, Nicolle A. Mode, Monica Bodogai, Yongqing Zhang, Elin Lehrmann, Alan B. Zonderman, Arya Biragyn, Josephine Egan, Kevin G. Becker, Mark P. Mattson, Ngozi Ejiogu, Michele K. Evans

#86:   Carboxypeptidase E-shRNA loaded exosomes as a potential therapeutic agent for suppression of tumor growth and metastasis
Sangeetha Hareendran, Bassam Albraidy, Xuyu Yang, and Y. Peng Loh

#89:   Transkingdom intercommunication at the vector-pathogen-host interface
Adela S. Oliva Chavez, Xiaowei Wang, Holly L. Hammond, Dana K. Shaw, Erin E. McClure, Amanda Buskirk, Marcela F. Pasetti, Steven M. Jay, Kateryna Morozova, Laura Santambrogio, Joao H.F. Pedra

#93:   Exosome DNA from cancer cells is methylated and reflects the methylation patterns of cells of origin
Jena Tavormina, Ming Tang, Olga Volpert, Kunal Rai, Raghu Kalluri

#97:   Therapeutic efficacy of mesenchymal stem cell-derived exosomes and microvesicles in preclinical models: A systematic review protocol
Alvin Tieu, Mitchell Slobodian, Dylan Burger, Dean A Fergusson, Duncan J Stewart, David Allan, Manoj M Lalu

#99:   Characterization and validation of a new microfluidic cytometry instrument for exosome sorting
Steven McClellan, Mary Patton, Girijesh Patel, Jin Akagi, Ajay Singh

#101:   Identifying membrane labels compatible with bead-based assays.
Kepley J.A., Welsh J.A., McKinnon K., Berzofsky J., Jones J.C.

#103:   EVs released from HIV-1 infected macrophages and Tat treated microglia inhibit glutamate transporter EAAT2 expression in astrocytes
Satish Deshmane, Prasun K. Datta

#105:   Extracellular Vesicles from Embryonic Stem cells Potentially Induce Pluripotency
Yun Ha Hur, Richard A. Cerione, Marc A. Antonyak

#107:   Detecting pancreatic ductal adenocarcinoma markers in tumor circulating exosomes
Veronica Sanchez, Aditya Dhande, Gabriel Reznik, David freedman, Min Ling, Bruno Bockorny, Manuel Hidalgo, Senthil K. Muthuswamy, George Daaboul

#109:   CD63 interactome analysis reveals important functions of CD63 in LMP1-dependent protein trafficking
Mujeeb Cheerathodi, Xia Liu, David G. Meckes Jr.

#111:   Semen Exosomes (SE) contain inhibitors of HIV-1 Reverse Transcriptase Activity
Adonis McQueen1, Hussein Kaddour, Chioma M Okeoma

#113:   Real-time monitoring exosome secretion by using dual luciferase reporter assay
Guoping Li, Shailesh Metkar, Kate Hartland, Maria Alimova, Virendar Kaushik, Saumya Das

#115:   Host ESCRT-dependent machineries guide Epstein-Barr virus LMP1 vesicle sorting
Dingani Nkosi, Mujeeb Cheerathodi, Mark A. Rider, David G. Meckes Jr.

#117:   Bone Marrow Stromal Antigen 2 (BST-2) promotes breast cancer invasion through extracellular vesicles
Tyler Panzner, Chioma M Okeoma

#119:   Mapping HIV-induced modifications in blood and semen exosomes surface charge
Hussein Kaddour, Jennifer L. Welch, Nadia Shouman, Jack T. Stapleton, Chioma M. Okeoma

#121:   Enrichment of Extracellular Vesicles Using Lipid Nanoprobes Functionalized Nanostructured Silica
Wan, Yuan; Maurer, Mackenzie; He, Hongzhang; Xia, Yiqiu; Hao, Sijie; Zhang, Wenlong; Yee, Nelson; Zheng, Si-Yang

#123:   Hypoxia mediated STAT3 activation plays a role in exosome secretion and contributes to ovarian cancer progression, metastasis and chemoresistance
Kalpana Deepa Priya Dorayappan, Michelle D.S. Lightfoot, Meghan M. Flannery, Colin L. Hisey, Derek Hansford, David E. Cohn, Karuppaiyah Selvendiran

#125:   The effect of RNA purification method on NGS profiling of Plasma miRNA expression
Vanja Misic, Bernard Lam, Moemen A.K. Abdalla, Yousef Haj-Ahmad

#127:   Detection of individual exosomes immobilized on surface by DNA-directed immune-capture chemistry
Ayca Yalcin Ozkumur, Dario Brambilla, Marcella Chiari, M. Selim Unlu

#129:   An Exosome Chronicle: shared and dissenting views on vesicle biology and methodology
Tine H. Schoeyen, Jan Lötvall

#131:   Characterization and functionality of stem cell-derived exosomes: potential for CNS repair
Heather Branscome, Siddhartha Paul, Alexei Miagkov, Catherine DeMarino, James Erickson, Fatah Kashanchi

#135:   Use of Nanotrap® Particles for Capture and Enrichment of Exosomes from Cell Culture Supernatant and Cerebrospinal Fluid
Ben Lepene, Monique Anderson, Yoshimi Enose‑Akahata, Maria Chiara Monaco, Setty Magana, Robbie Barbero, Fatah Kashanchi, Steven Jacobson

#137:   Cytokine-induced extracellular vesicles increase mitochondrial function in recipient cells
Ashley E. Russell, Sujung Jun, Saumyendra Sarkar, Sara E. Lewis, Stephanie L. Rellick, James W. Simpkins

#139:   Ebola VP40 regulates extracellular vesicle biogenesis to cause immune cell dysfunction.
M. L. Pleet, J. Erickson, C. DeMarino, A. Mathiesen, M. Cowen, R. Barclay, S. Iordanskiy, G. Sampey, L.I. Prugar, S. W. Stonier, J.M. Dye, W. Zhou, L.A. Liotta, B. Lepene, M.J. Aman, F. Kashanchi

#141:   The role of exosomes in maintaining terminal differentiation in epithelial cells
Mi Zhou, Sarah R. Weber, Yuanjun Zhao, Yuka Imamura, Jeffrey M. Sundstrom

#143:   Analysis of vitreous extracellular vesicles in retinal disease
Sarah R. Weber, Yuanjun Zhao, Thomas W. Gardner, Jeffrey M. Sundstrom

#145:   Extracellular vesicles secreted by fetal neural stem cells: novel targets and mediators of the teratogenic effects of ethanol
Dae Chung, Marisa Pinson, Alexander Tseng, Nihal Salem, Sridevi Balaraman, Amanda Mahnke, Sunwoo Koo, Larry Dangott, Rajesh C. Miranda

#147:   Acute effects of a single glucocorticoid dose on miRNAs and exosomal proteins in young adult volunteers
Runia Roy; Alyson Fiorillo; Christopher Heier; Alison Samsel; Mansi Goswami; Tchilabalo Alayi; Swati Mummidivarpu; Marissa Barbieri; Nicole Rouhanna; Ann Fronczek; Yetrib Hathout; Eric Hoffman

#149:   A genetic screen for Cryptococcus neoformans EV release uncovers a role for nickel toxicity in EV release due to lack of NIC1 nickel transporter
JM Wolf, C Coelho, M Garcia-Solache, R Vij, S Slocum, Cd Leon-Rodriguez, A Jedlicka, A Casadevall

#151:   The Role of Autophagy and Antiretroviral Drugs on Extracellular Vesicle Release and Associated CNS Dysfunction
DeMarino C, Pleet ML, Cowen M, Barclay RA, Noren Hooten N, Lepene B, Royal W 3rd, Liotta LA, Kashanchi F

#153:   Extracellular vesicles released by commensal Lactobacillus decrease HIV-1 infection
Rogers Alberto Nahui Palomino, Christophe Vanpouille, Beatrice Vitali, Leonid Margolis

#155:   Scalable method for isolation of pure and functional exosomes from cell culture media
Siddhartha Paul, Heather Branscome, Nanda Mahashetty, Sheela Jacob, Dezhong Yin, Robert Newman

#157:   Monitoring immunophenotypes of single extracellular vesicles by nano-flow cytometry
Dongsic Choi, Laura Montermini, Hyeonju Jeong, Brian Meehan, Janusz Rak

#159:   A novel mechanism of neurotoxicity in Alzheimer’s disease: astrocyte-derived extracellular vesicles
Carlos J Nogueras-Ortiz, Edward J Goetzl, Vasiliki Machairaki, Dimitrios Kapogiannis

#161:   The landscape of extracellular RNA with human age
Nicole Noren Hooten, Douglas F. Dluzen, Supriyo De, William H. Wood III, Yongqing Zhang, Kevin G. Becker, Alan B. Zonderman, Toshiko Tanaka, Luigi Ferrucci, Michele K. Evans

#163:   Cellular Manipulation through Cell Penetrating Peptide-Loaded Exosome Transfer
Jason K. Allen, Jean-Philippe Pellois

#165:   Setting Benchmarks for Robust and Reproducible Nanoparticle Tracking Analyses
Agnieszka Siupa, Duncan Griffiths, Pauline Carnell-Morris, Candice Warner, Arianna Biesso, Matthew McGann

#167:   Comparability of the small RNA secretome across human biofluids concomitantly collected from healthy adults
Scott M Langevin, Damaris Kuhnell, Jacek Biesiada, Xiang Zhang, Mario Medvedovic, Glenn Talaska, Katherine Burns, Susan Kasper

#169:   Cancer-derived Large Oncosomes reprogram bone marrow mesenchymal stem cells
Blandine F. Victor, MS; Juliane Glaeser, PhD; Andrew Chin, PhD; Tatyana Vagner, PhD; Javier Mariscal, PhD; Minhyoung Kim, PhD; Mandana Zandian, MD; Khosrowdad Salehi, BS; Sungyong You, PhD; Dmitriy Sheyn, PhD; Dolores Di Vizio, MD, PhD

#171:   Extracellular inflammatory messages in HIV infection and cigarette use: a role for small RNAs?
Bonita Powell, Ken Witwer

8:30am – 12:00pm

Chair: Christie Fowler, UC Irvine, Irvine, USA

8:30 – 8:45am Circulating extracellular vesicles are biomarkers and mediators of alcoholic liver
disease
Gyongyi Szabo University of Massachusetts, Worcester, USA (abstract #54)

8:45 – 9:00am Extracellular vesicle biomarkers for preclinical prediction of Alzheimer’s disease
Dimitrios Kappogianis NIA/NIH, Baltimore, USA (#55)

9:00 – 9:15am Placental exosomes in maternal-placental-fetal communication & viral resistance
Yoel Sadovsky Pittsburgh University, Pittsburgh, USA (#56)

9:15 – 9:30am The molecular interaction between exosomal ceramide and beta amyloid reveals
a role for ceramide in Abeta aggregation & toxicity
Ahmed Elsherbini University of Kentucky, Lexington (KY) USA (#57)

9:30 – 9:45am Investigating the role of fibulin-3 and exosomes in macular degeneration
Jasmine Geathers Penn State University, Hershey, USA (#58)

9:45 – 10:00am Immortalised human neural stem cell platform for the production of exosome-
based therapeutics
Randolph Corteling ReNeuron, Cardiff, UK (#59)

10:00 – 10:30am Break

10:30 – 10:45am Blood based assays for the diagnosis and stratification of glioma patients
Leonora Balaj MGH/Harvard, Boston, USA (abstract #60)

10:45 – 11:00am Phospholipids within extracellular vesicles may contribute to the activation of
target cells
Antonio de Maio UCSD, San Diego, USA (#61)

11:00 – 11:15am Metabolic control of outer membrane vesicle production in Francisella spp.
Vinaya Sampath Long Island University-Post, Brookville, USA (#62)

11:15 – 11:30am Characterization of microvesicles for cancer diagnostics
John Semmes EVMS, Norfolk, USA (#63)

11:30 – 11:45am Evaluation of a microvesicle-based poly-ligand opt-out assay for screening plasma
samples from men at risk for prostate cancer
Heather O’Neill CARIS Life Sciences, Phoenix, USA (#64)

11:45am – 12:00pm Role of exosomal miRNAs as a biomarker for mitochondrial dysfunction
Michael Paulaitis Johns Hopkins University, Baltimore, USA (#65)

12:00pm – 1:30pm Lunch

1:30pm – 5:00pm

Chair: Andries Zijlstra, Vanderbilt University, Nashville, USA

1:30 – 1:45pm Extracellular vesicles from embryonic stem cells potentially induce pluripotency
Marc Antonyak Cornell University, Ithaca, USA (abstract #66)

1:45 – 2:00pm Preanalytical steps enabling optimal exosome based liquid biopsy in cancer
Antonio Chiesi Exosomics/HansaBioMed/Lonza, Sienna, Italy (#67)

2:00 – 2:15pm Exosomes from pancreatic cancer stem cells mediate intra tumor communication
and facilitate Hippo pathway regulation
Sonia Melo University of Porto, Porto, Portugal (#68)

2:15 – 2:30pm Effect of exosomes on macrophage polarization state
Joshua Hood University of Louisville, Louisville, USA (#69)

2:30 – 2:45pm Liquid biopsy: circulating tumor exosomes’ lineage traced back to their cell and
tissue of origin
Navneet Dogra IBM, New York, USA (#70)

2:45 – 3:00pm miRNA profiling from EVs utilizing FirePlex technology
Brendan Collins Abcam, Cambridge, USA (#71)

3:00 – 3:30pm Break

3:30 – 3:45pm Detection of an EV-based metastasis signature in clinical biofluids
John Lewis University of Alberta, Alberta, Canada (#72)

3:45 – 4:00pm Monitoring binding and internalization of EVs in blood cell subsets
Sherree Friend MilliporeSigma (Amnis), Seattle, USA (#73)

4:00 – 4:15pm Host exosomes: the molecular shuttle hijacked by human Cytomegalovirus?
Rommel Mathias Monash University, Melbourne, Australia (#74)

4:15 – 4:30pm An efficient and high-purity method for EV isolation from urine samples
Gayatri Premasekharan System Biosciences, Palo Alto, USA (#75)

4:30 – 4:45pm Isolation of molecularly homogeneous subpopulations of exosomes
Mikhail Skliar University of Utah, Salt Lake City, USA (#76)

4:45 – 5:00pm Exosomes promote cancer progression by regulating the anti-tumor immune
response
Mauro Poggio UCSF, San Francisco, USA (#77)

7:30pm – 9:30pm

Chair: Xandra Breakefield, MGH/Harvard, Boston, USA

7:30 – 7:50pm Biological nanoparticles as therapeutic agents
Tushar Patel Mayo Clinic, Jacksonville, USA (abstract #78)

7:50 – 8:10pm Leveraging machine-learning assisted histopathology to assess large oncosome
biogenesis in tissue
Andries Zijlstra Vanderbilt University, Nashville, USA (#79)

8:10 – 8:30pm Hitchhiking extracellular vesicles to jump: Extracellular vesicles serve as delivery
vehicles for LINE-1 retrotransposons
Yumi Kawamura National Cancer Center, Tokyo, Japan (#80)

8:30 – 8:50pm Tools for live-monitoring of exosomes release from single cells
Maarten Bebelman VU University, Amsterdam, The Netherlands (#81)

8:50 – 9:10pm Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy
individuals and patients with pancreatic cancer
Pedro Correa de Sampaio MD Anderson Cancer Center, Houston, USA (#82)

9:10 – 9:30pm Virosomes: How an infected cell tolerates its viral pathogen using the exosomal
pathway
Catherine DeMarino George Mason University, Manassas, USA (#83)

8:30am – 12:00pm

Chair: Dolores Di Vizio, Cedars Sinai, Los Angeles, USA

↪ ASEMV Discovery Lecture ↩
8:30 – 9:00am EV-mediated RNA transfer in glioblastoma
Xandra Breakefield MGH/Harvard, Boston, USA (abstract #84)

9:00 – 9:15am Diabetes mellitus alters extracellular vesicle concentration, cargo and function
Nicole Noren Hooten NIA/NIH, Baltimore, USA (#85)

9:15 – 9:30am Carboxypeptidase E-shRNA loaded exosomes as a potential therapeutic agent for
suppression of tumor growth and metastasis
Peng Loh NICHD/NIH, Washington DC, USA (#86)

9:30 – 9:45am The α5β1 integrin is crucial for prostate cancer exosome tumorigenic function
Rachel DeRita Thomas Jefferson University, Philadelphia, USA (#87)

9:45 – 10:00am Extracellular vesicles in oncogenic signaling and autophagy
Stephanie Hurwitz Florida State University, Tallahassee, USA (#88)

10:00 – 10:30am Break

10:30 – 10:45am Transkingdom intercommunication at the vector-pathogen-host interface
Joao H.F. Pedra University of Maryland, Baltimore, USA (#89)

10:45 – 11:00am Characteristics of PS-affinity method for isolation & detection ofEVs: advantages c
clarified from comparison with conventional methods
Sadamu Ozaki FUJIFILM ako Pure Chemical Corporation, Osaka, Japan (#90)

11:00 – 11:15am Where’s my peak?: separating truth from fiction in label-free measurements of
EVs
Jean-Luc Fraikin Spectradyne, Inc., Torrance, USA (#91)

11:15 – 11:30am An optimized UC method versus SEC for isolation of exosomes from serum
David Lubman University of Michigan, Ann Arbor, USA (#92)

11:30 – 11:45am Exosome DNA from cancer cells is methylated and reflects the methylation
patterns of cells of origin
Jena Tavormina MD Anderson Cancer Center, Houston, USA (#93)

11:45am – 12:00pm Profiling the vesicular and non-vesicular miRNA secretome
Imre Mager University of Oxford, Oxford, UK (#94)

12:00pm – 1:30pm Lunch

1:30pm – 4:15pm

Chair: Norm Haughey, Johns Hopkins University, Baltimore, USA

1:30 – 1:45pm A bright, versatile reporter to track exosome secretion
Bong Hwan Sung Vanderbilt University, Nashville, USA (abstract #95)

1:45 – 2:00pm Extracellular vesicles carry gp120 and facilitate HIV infection in human lymphoid
tissue ex vivo
Anush Arakelyan NICHD/NIH, Washington DC, USA (#96)

2:00 – 2:15pm Therapeutic efficacy of mesenchymal stem cell-derived exosomes & microvesicles
in preclinical models: A systematic review protocol
Alvin Tieu OHRI, Ottawa, Canada (#97)

2:15 – 2:30pm Automated and rapid labelling of vesicles using acoustic trapping
Mikael Evander Acousort, Lund, Sweden (#98)

2:30 – 2:45pm Characterization and validation of a new microfluidic cytometry instrument for
exosome sorting
Steven McClellan USA Mitchell Cancer Institute, Mobile, Alabama (#99)

2:45 – 3:00pm Understanding exosome biogenesis in hypothalamic cells through studying of
protein dynamic using pulsed-silac
Chee Fan Tan NTU, Singapore (#100)

3:00 – 3:15pm Identifying membrane labels compatible with bead-based assays
Julia Kepley NCI/NIH, Washington DC, USA (#101)

3:15 – 3:30pm Increased secretion of miR-193a-3p by cardiomyocytes under stress inhibits
proliferation and activation of cardiac fibroblasts
Rodosthenis Rodosthenous MGH/Harvard, Boston, USA (#102)

3:30 – 3:45pm EVs released from HIV-1 infected macrophages and Tat treated microglia inhibit
glutamate transporter EAAT2 expression in astrocytes.
Prasun Datta Temple University, Philadelphia, USA (#103)

3:45 – 4:00pm Inflaming the masses: glioma EVs promote inflammatory, degradative, and metabolic responses in normal brain cells
Michael Graner University of Colorado, Denver, USA (#104)

4:00 – 4:15pm Extracellular vesicles from embryonic stem cells potentially induce pluripotency
Marc Antonyak Cornell University, Ithaca, USA (#105)

Meeting close
Stephen Gould, Johns Hopkins University, Baltimore, USA