ASEMV2019 — Conference Program

9:30am – 2:45pm

See the Technology Working Group page for a complete agenda.

7:00pm – 9:00pm

Chair: Michael Graner, University of Colorado, Denver, USA

7:00 – 7:15pm Welcome
Michael Graner, University of Colorado, Denver, USA

7:15 – 8:00pm Arc And Copia In Exosome-Mediated Information Exchange
Travis Thomson, U. Massachusetts, Worcester, MA, USA (1)

8:00 – 8:30pm Reassessment of Exosome Biogenesis
Stephen Gould, Johns Hopkins University, Baltimore, USA (2)

8:30 – 9:00pm Synopsis Of The ASEMV Technology Working Group
Louise Laurent, UCSD, San Diego, CA, USA (3)

9:00 – 11:00pm Reception

8:30am – 12:30pm

Chair: Tijana Talisman, City of Hope, Duarte, USA

8:30 – 8:50am Extracellular Vesicles As Functional Biomarkers In Manifestations Of Heart Failure
Saumya Das, MGH, Boston, MA, USA (4)

8:50 – 9:10am Excessive Exosome Release Elicits A Pathogenic Cascade That Links A Lysosomal Deficiency To Generalized Fibrosis
Alessandra d’Azzo, St. Jude Children’s Research Hospital , Memphis TN, USA (5)

9:10 – 9:30am Biofunctional peptide-modified extracellular vesicles for macropinocytosis induction and intracellular delivery
Ikuhiko Nakase, Osaka Prefecture University, Osaka, Japan (6)

9:30 – 9:50am Methamphetamine Use Disorder Alters Plasma Extracellular Vesicle MicroRNA Expression
Ursula Sandau, OHSU, Portland, OR, USA (7)

9:50 – 10:10am Multiplexed Profiling Of Single Extracellular Vesicles
Ala Jo, MGH/Harvard, Boston, MA, USA (8)

10:10 – 10:30am Break

10:30 – 10:50am 4-Color Immunophenotyping Of Extracellular Vesicles
Sven Kreutel, ParticleMetrix, Meerbusch, Germany (9)

10:50 – 11:10am Multi-Parametric Inteferometric Enhanced Imaging Allows For Single Particle Analysis
George Daaboul, NanoView, Boston, MA, USA (10)

11:10 – 11:30am Automated, High-Precision Extracellular Vesicle Isolation
Shayne Harrel, Izon Science, Boston, MA, USA (11)

11:30 – 11:50am A Novel, Plate-Based Method For High-Throughput EV Isolation
Victoria Portnoy, System Biosciences (SBI) Palo Alto, CA, USA (12)

11:50am – 12:10pm The Importance Of Orthogonal Techniques In Quantifying Extracellular Vesicles
Franklin Monzon, Spectradyne, Torrance, CA, USA (13)

12:10am – 12:30pm NIH Common Fund’s Extracellular RNA Communication Program
Christine Happel, NCATS/NIH, Bethesda, MD, USA (14)

12:30pm – 1:30pm Lunch
1:30pm – 6:00pm Break
6:00pm – 6:45pm Dinner

7:00pm – 9:00pm

Chair: Stephen Gould, Johns Hopkins University, Baltimore, USA

7:00 – 7:30pm Resolving EV Subpopulation Heterogeneity Through Dimensional Reduction Of Multi-Parametric Flow Cytometry Data
Andries Zijlstra, Vanderbilt U. Medical Center, Nashville, TN, USA (15)

7:30 – 8:00pm Extracellular Vesicle Characterization With Quantitative Single Molecule Localization Microscopy
Tijana Talisman, City of Hope, Duarte, CA, USA (16)

8:00 – 8:20pm Searching For ALS Biomarkers In Neural-Derived Exosomes
Sandra Banack, Institute for Ethnomedicine, Jackson, WY, USA (17)

8:20 – 8:40pm Exosomes From Synovial Fluid Facilitate Transport Of Osteoarthritis Biomarkers And Proteins Inducing Cartilage Degradation
Malwina Czarny-Ratajczak, Tulane U. New Orleans, LA, USA (18)

8:40 – 9:00pm Extracellular Vesicles Released By Commensal Lactobacillus Suppress HIV-1 Infection
Christophe Vanpouille, NICHD/NIH, Bethesda, MD, USA (19)

8:30am – 12:00pm

Chair: Dirk Dittmer, UNC Chapel Hill, Chapel Hill, NC, USA

8:30 – 8:50am Extracellular Vesicles From Kaposi Sarcoma-Associated Herpesvirus Lymphoma Induce Long-Term Endothelial Cell Reprogramming
Ryan McNamara, UNC Chapel Hill, Chapel Hill, NC, USA (20)

8:50 – 9:10am High Throughput Isolation And Purification Of Exosomes Using Hydrophobic Interaction Chromatography On Capillary-Channeled Polymer (C-CP) Fiber Phases
Ken Marcus, Clemson U., Clemson, SC, USA (21)

9:10 – 9:30am Viral Scission Factor Alix Tunes Neuronal Communication Through Extracellular Vesicles
Jeffrey Savas, Northwestern U. Chicago, IL, USA (22)

9:30 – 9:50am Tissue Stiffness Modulates Extracellular Vesicle Function In Metastatic Breast Cancer
Alexandra Sneider, Johns Hopkins University, Baltimore, MD, USA (23)

9:50 – 10:10am Exosomes As Novel Mediators Of Pro-Inflammatory Cytokine-Induced Β-Cell Dysfunction In Diabetes
Naureen Javeed, Mayo Clinic, Rochester, MN, USA (24)

10:10 – 10:40pm Break

10:40 – 11:00am Renal Tubular Exosomes Modulate Extracellular Levels Of ATP In A Nephron-Segment Specific Fashion
Eric Barros, Universidad Católica de Chile, Santiago, Chile (25)

11:00 – 11:20am Association Of Aβ With Astrocyte-Derived And Ceramide-Enriched Exosomes Mediates Aβ Mitotoxicity In Neurons Which Is Prevented By Novel Ceramide Analogs
Simone Crivelli, U. Kentucky, Lexington, KY, USA (26)

11:20 – 11:40am Transport Of Outer Membrane Vesicles Between Pathogenic And Commensal Bacteria
Shannon Collins, Lehigh U. Lehigh, PA, USA (27)

11:40am – 12:00pm The Role Of Extracellular Vesicles (Evs) And EV-Cargo In Virally-Mediated CNS Diseases
Setty Magaña, NINDS/NIH, Bethesda, MD, USA (28)

12:00 – 1:30pm Lunch
1:30 – 6:00pm Break
6:00 – 6:45pm Dinner

7:00pm – 9:00pm

Chair: Janice Braun, U. Calgary, Calgary, Canada

7:00 – 7:30pm Opioids And NeuroHIV: Blaming The Messengers
Shilpa Buch, U. Nebraska, Omaha, NE, USA (29)

7:30 – 8:00pm Distinct Mechanisms Of Microrna Sorting Into Cancer Cell-Derived Extracellular Vesicle Subtypes
Morayma Temoche-Diaz, UC Berkeley, Berkeley, CA, USA (30)

8:00 – 8:20pm Milk Derived Exosomes For siRNA Delivery
Farrukh Aqil, U. Louisville, Louisville, KY, USA (31)

8:20 – 8:40pm Knockout Of Maternal Tsg101 And Dicer Impair Gut Health In Suckling Wild-Type Pups
Janos Zempleni, U. Nebraska, Lincoln, NE, USA (32)

8:40 – 9:00pm Extracellular Vesicles And The Maintenance Of Pluripotency In Embryonic Stem Cells
Yun Ha Hur, Cornell University, Ithaca, NY, USA (33)

8:30am – 12:00pm

Chair: Shilpa Buch, U. Nebraska, Omaha, NE, USA

8:30 – 9:00am Vesicular MicroRNAs Orchestrate The Biology Of The Tumor Microenvironment
Muller Fabbri, U. of Hawai’i Cancer Center, Honolulu, HI, USA (34)

9:00 – 9:30am Cancer-Derived Extracellular Vesicles And Large Oncosomes: From Biology To Biomarkers
Dolores Di Vizio, Cedars Sinai Medical Center, Los Angeles, CA, USA (35)

9:30 – 9:50am FCMPASS V3, A New Software Tool For Flow Cytometry, Provides Methods For Determining EV Size And For Reporting Fluorescence And Light Scatter Data In Standard Units
Joshua Welsh, NCI/NIH, Bethesda, MD, USA (36)

9:50 – 10:10am Establishing The Contributions Of Extracellular Micrornas To Alzheimer’s Disease
Julie Saugstad, OHSU, Portland, OR, USA (37)

10:10 – 10:40am Break

10:40 – 11:00am The NE+ Neutrophil Exosome Is A Promising Therapeutic Target In A Mouse Model Of COPD
Derek Russell, U. Alabama Birmingham, Birbingham, AL, USA (38)

11:00 – 11:20am Exosome-Associated Protein Alix As A Novel Diagnostic Marker For Oral Squamous Cell Carcinoma
Eiji Nakamichi, Nagoya University, Nagoya, Japan (39)

11:20 – 11:40am Phosphorylation Of Tyrosine 23 In Annexin A2 Is Essential For Its Association With Exosomes And For Imparting Invasive And Proliferative Capacity To Other Cells
Priyanka Desai, U. North Texas HSC, Ft. Worth, TX, USA (40)

11:40am – 12:00pm Engineering ARMMS For Efficient Delivery Of Cas9 Genome Editors
Quan Lu, Harvard SPH, Boston, MA, USA (41)

12:00 – 2:00pm Lunch, etc.

2:00pm – 4:00pm

Chair: Muller Fabbri, U. Hawai’i, Honolulu, HI, USA

2:00 – 2:20pm Extracellular Vesicles From Cardiosphere-Derived Cells (Cdcs) Are Taken Up By Muscle Stem Cells And Increase Exercise Capability In A Duchenne Muscular Dystrophy Model
Luis Rodriguez-Borlado, Capricor Therapeutics, Beverly Hills, CA, USA (42)

2:20 – 2:40pm Surface Proteoglycan Facilitates Elastase Binding On Neutrophil Derived Exosomes
Kristopher Genschmer, U. Alabama Birmingham, Birmingham, AL, USA (43)

2:40 – 3:00pm Exosomes Regulate Neurogenesis And Circuit Assembly To Rescue A Human Ipsc Model Of Rett Syndrome
Pranav Sharma, Scripps Research Institute, La Jolla, California (44)

3:00 – 3:20pm MRI-Navigated Focused Ultrasound Validation For Delivery Of Small Molecules And Exosomes Among Alzheimer’s Patients
Barshen Habelhah, Neurological Associates, Intervention Group, Los Angeles, CA, USA (45)

3:20 – 3:40pm Properties Of Extracellular Vesicles Derived From Primed Mesenchymal Stem Cells
Johnathon Anderson, UC Davis, Davis, CA, USA (46)

3:40 – 4:00pm Quantitative Proteomics Analysis Of Lipotoxic Mouse Hepatocyte Extracellular Vesicles
Yasuhiko Nakao, Mayo Clinic, Rochester, MN, USA (47)

6:00 – 6:45pm Dinner

7:00pm – 9:00pm

Chair: Jennifer Jones, NCI/NIH, Bethesda, MD, USA

7:00 – 7:30pm Macrophage-Exosomes Control Hematopoiesis & Inflammation In Diabetic Atherosclerosis
Robert Raffai, UCSF/VA, San Francisco, CA, USA (48)

7:30 – 8:00pm Identification Of Evs That Deliver Proteins Across The Blood-Brain Barrier
Janice Braun, U. Calgary, Calgary, Canada (49)

8:00 – 8:20pm Problems Inside And Out: Glioma Evs Alter Signaling, Metabolism, And The Extracellular Environment Of Normal Brain Cells
Michael Graner, U. Colorado Anschutz, Denver, CO, USA (50)

8:20 – 8:40pm Tumor Derived Extracellular Vesicles Induced Immunosuppression Is Reversible With A Single Peptide Checkpoint Inhibitor
Michael Olin, U. Minnesota, Minneapolis, MN, USA (51)

8:40 – 9:00am Extracellular Vesicle Associated Microrna-29a Elicits Microglial Activation And Synaptodendritic Injury During Chronic Methamphetamine Abuse
Sowmya Yelamanchili, U. Nebraska-Lincoln, Lincoln, NE, USA (52)

9:00am – 12:00pm

Chair: Robert Raffai, UCSF/VA, San Francisco, CA, USA

9:00 – 9:30am Discovery And Verification Of Extracellular Mirna Biomarkers For Non-Invasive Prediction Of Preeclampsia In Asymptomatic Women
Louise Laurent, UCSD, San Diego, CA, USA (53)

9:30 – 10:00am Astrocyte-Derived Extracellular Vesicles Shed In Response To IL-1 Promote Stabilization Of APP Translation Through Ligand-Independent Activation Of The Wnt Pathway In Neurons
Norman Haughey, Johns Hopkins U. Baltimore, MD, USA (54)

10:00 – 10:30am TBD
John Lewis, U. Alberta, Alberta, Canada (55)

10:30 – 11:00am Break

11:00 – 11:20am Microvesicle-Mediated Delivery Of Minicircle DNA Results In Effective Gene Directed Enzyme Prodrug Cancer Therapy
Masamitsu Kanada, Michigan State U., East Lansing, MI, USA (56)

11:20am – 11:40pm Liquid Biopsy: Prostate Cancer Patient’s Tumor RNA Lineage Exist In Serum And Urine Exosomes
Navneet Dogra, IBM & Mt. Sinai, Yorktown Ht.s & NYC, NY, USA (57)

11:40am – 12:00pm Extracellular Vesicle Concentrations In Human Plasma And Serum As Revealed By Microfluidic Resistive Pulse Sensing And Size Exclusion Chromatography Coupled With On-Line Fluorescence Detection
Zoltan Varga, Hungarian Academy of Sciences, Budapest, Hungary (58)

12:00 – 1:30pm Lunch

1:30pm – 4:00pm

1:30 – 1:50pm Differences In The Transcriptomic And Proteomic Analyses Of Peritoneal Cells Exposed To Phosphatidylcholine Liposomes
Antonio De Maio, UCSD, San Diego, CA, USA (59)

1:50 – 2:10pm The Mutation Of R345W In Fibulin-3 Causes RPE To Undergo Epithelial-Mesenchymal Transition And Alters Its Exosome Cargo
Mi Zhou, Penn State, Hershey, PA, USA (60)

2:10 – 2:30pm Mechanical Tension Influences MSC-Derived Exosomes And Their Regulation Of Wound Healing And Fibrotic Phenotype: Novel Frontiers In Regenerative Tissue Repair
Hima Vangapandu, Baylor College of Medicine, Baylor, TX, USA (61)

2:30 – 3:00pm Exosomal Proteomics Identifies Machinery Able To Inhibit Anti Tumor Immunity
Mauro Poggio, UCSF, San Francisco, CA, USA (62)

3:00 – 4:00pm ASEMV business & meeting close