October 16–20, 2015
Marco Island Marriott Beach Resort, Golf Club & Spa
Marco Island, Florida

Program Detail

Friday Oct 16, 2015
Session I
Chair: Michael Graner

Michael Graner, University of Colorado
Opening of ASEMV2015

Lawrence Rajendran
Beckman/Coulter Lecture: Role of membrane trafficking in Alzheimer’s disease

Johan Skog, Exosome Diagnostics
Exosome-based clinical testing: application to prostate cancer

Opening reception

Saturday Oct 17, 2015
Session II
Co-Chairs: Xandra Breakefield & Johan Skog

Louise Laurent, UC San Diego
Discovery of extracellular miRNA biomarkers for placental dysfunction

Florin Selaru, Johns Hopkins University
Treatment of desmoplastic cancers with extracellular vesicles

Alissa Weaver, Vanderbilt University
KRAS signaling regulates Argonaute 2 (Ago2) and miRNA sorting into exosomes

Fatah Kashanchi, George Mason University
Exosome from latent virally infected cells including HIV, HTLV-1, RVFV, and Ebola control innate immune response in recipient cells

Ritankar Majumdar, NCI/NIH
Exosomes Mediate LTB4 Release During Neutrophil Chemotaxis

Tomas Szul, University of Alabama Birmingham
Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes

Harmeet Malhi, Mayo Clinic
IRE1alpha mediates the release of ceramide enriched extracellular vesicles from hepatocytes which activate macrophages

Masamitsu Kanada, Stanford University
Extracellular vesicle-mediated delivery of prodrug-converting enzymes for cancer therapy

Maria Mirotsou, Capricor Therapeutics
Development of cardiosphere-derived cell extracellular vesicles for regenerative medicine

Travis Antes, SystemsBiosciences
Engineering Therapeutic Nanoshuttles

Session III
Chair: Lawrence Rajendran

Stefan Momma, University Hospital Frankfurt
Caris Discovery Lecture: Tracing extracellular vesicle-mediated transfer of functional RNA in vivo

Dolores Di Vizio, Cedars Sinai
Tumor-derived large oncosomes contain kinase activity and can modulate transcription factor activation in the tumor environment

Exosome Stories (Various Speakers)

Evening Poster Session A/Reception

Sunday Oct 18, 2015
Session IV
Co-Chairs: Alissa Weaver and Fatah Kashanchi

Xandra Breakefield, MGH/Harvard
Extracellular RNA in brain tumors – saboteurs and biomarkers

Clark Chen, UC San Diego
CSF exosomal miRNAs as a biomarker platform for glioblastoma

John Semmes
Targeting extracellular vesicles for biomarker discovery and as potential assay vehicles

Muller Fabri, University of Southern California
Exosomic microRNA exchange promotes drug resistance

Y. Peng Loh, NICHD/NIH
Carboxypeptidase E: A prognostic cancer biomarker in tumors and circulating exosomes

Goran Ronquist
Proteomic Profiling of Detergent Resistant Membranes (Lipid Rafts) of Prostasomes

Andrew Hoffman, Tufts University
Are exosomes the next nanotheranostic frontier for cardiac disease? Explorations in a canine spontaneous mitral valve disease model

Sasha Vlassov, Life Technologies
Exosomes as source of biomarkers

Huiping Liu, Case Western Reserve University
Developing exosome-based therapeutics targeting cancer stem cells

A. C. Matin, Stanford University
Use of a new visualizable prodrug regimen for specific targeting of Her2 positive breast cancer using exosomes

Session V
Chair: Stephen Gould

Geoffrey de Couto, Cedars Sinai Heart Institute
Biodistribution of cardiosphere-derived cell exosomes: preferential uptake and polarization by macrophages after systemic delivery

Norman Haughey, Johns Hopkins University
Exosystems regulate communication between the brain and immune system via the liver

L. Shannon Holliday
Extracellular vesicles released by osteoclasts inhibit osteoclastogenesis in 1,25- dihydroxyvitamin D3-stimulated mouse marrow cultures

Evening Poster Session B/Reception

Monday Oct 19, 2015
Session VI
Chair: Stephen Gould

Michael Graner, University of Colorado
Transcriptional regulator proteins in EVs: the potential to mediate downstream pathways

Jeff Franklin, Vanderbilt University
Oncogene patterning of the tumor microenvironment via exosomes

Mikhail Skliar, University of Utah
Size and shape characterization of serum extracellular vesicles in hydrated and dessicated forms

Antonio De Maio, UC San Diego
Heat shock increases the production of extracellular vesicles

Janos Zempleni, University of Nebraska
The intestinal transport of bovine milk exosomes is mediated by endocytosis in human colon carcinoma Caco-2 cells and rat small intestinal IEC-6 cells

Martin Schlumpberger, Qiagen
Rapid Isolation of Intact Exosomes and Extracellular Vesicles

Kirsi Rilla, University of Eastern Finland
Correlative light and electron microscopy is a powerful method to study interactions of extracellular vesicles with recipient cells

Erez Eitan, NIA/NIH
Lysosome status modulates exosome functions in intercellular signaling and intracellular protein disposal

Sarah Fernando, University of British Columbia
Extracellular vesicles from amyotrophic lateral sclerosis tissues have misfolded SOD1 cargo and are implicated in propagation of protein misfolding